Reward, Rest, and Antidepressant Drug Action

Autoregulation of serotonin neurons: role in antidepressant drug action.

[Neuropsychological cognitive hypothesis of antidepressant drug action--literature review].

Depression is a state characterised by the psychobiological symptoms included in the international classifications. People suffering from depression, apart from the primary and auxiliary symptoms of this disorder, have specific emotional-cognitive schemas. They tend to interpret a neutral sign as a negative one more often. According to some researchers, using antidepressants can change an "auto...

Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action.

We previously reported that the activity of mesolimbic dopamine neurons of the ventral tegmental area (VTA) is a key determinant of behavioral susceptibility vs resilience to chronic social defeat stress. However, this was based solely on ex vivo measurements, and the in vivo firing properties of VTA dopamine neurons in susceptible and resilient mice, as well as the effects of antidepressant tr...

Redesigning antidepressant drug discovery

Antidepressant drug discovery and development have been put on hold by many pharmaceutical companies. The main reason for this is the negative efficacy studies with novel specific drugs. Here I argue that the main obstacles are the absence of gene tests and biomarkers as an integral part of a diagnostic process. Further, too much emphasis has been put on validating drug candidates in animal mod...

Selecting selectivities and the neuropharmacology of antidepressant drug action: a commentary.

Scientific Advisor: David B. Bylund, University of Nebraska Medical Center, Omaha, Nebraska, USA. Scientific Reviewers: Solomon H. Snyder, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; and Frederick Petty, Creighton University School of Medicine, Omaha, Nebraska, USA. Breakthroughs in Bioscience Committee: David L. Brautigan, University of Virginia School of Medicine, C...